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individuals may have received identical diagnoses, there can be substantial behavioral variability among group members As a result, inferences made by averaging across individual patients can be imprecise (Caramazza, 1986; Caramazza & Badecker, 1989) Caramazza and Badecker (1989) argue further that manifestations of lesions can differ across individuals, therefore rendering inferences about normal cognitive function unreliable (see also Shallice, 1988) Some researchers therefore feel that the only way in which to make conclusions regarding the structure of cognitive systems is to investigate single cases, and to make subsequent comparisons across patients This idea has led to the notion of multiple single-case studies as an alternative to group research In this approach, each patient participates in the same experiment, but techniques such as averaging across individuals are not employed We believe that a hybrid approach strikes a reasonable compromise between group and singlecase advocates on this point.

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When predicting and analyzing a directional group difference on some cognitive variable, it is useful not only to report measures of central tendency (means, medians, etc), but also to report how many individual patients show the predicted effect Arguments in favor of group-based lesion studies advocate that in some instances, group studies can be more effective at distinguishing very discrete components of cognitive systems (Robertson, Knight, Rafal, & Shimamura, 1993; Zurif et al, 1991) Although these researchers do not dismiss the use of single-case studies in drawing inferences about normal cognitive function, they believe that useful information can be obtained from analysis of neuropsychological syndromes (Zurif et al, 1991) One key problem in group research is the variability of symptom presentations seen in most neuropsychological syndromes Thus, for example, not all patients with Broca s aphasia or Gerstmann s syndrome present with precisely the same symptoms.

The use of lled polymer for circuit protection was initiated in the early 1980s, with a selfresetting polymer fuse that had the capability of resetting after a current surge [9,10]. In these structures, the materials increase in resistance as a function of current. Polymer positive temperature coef cient (PPTC) devices are used across all electronic markets because of their re-set feature and their formation into low pro le lms [9,10].

Thus, in searching for behavioral precision in group studies, the need to establish necessary and suf cient inclusionary and exclusionary criteria is obvious This issue is similar in kind to the historical controversies in clinical psychiatry that led to the development of research diagnostic criteria for major mental disorders (Spitzer, Endicott, & Robins, 1978) Operationally de ned criteria sets have been developed for certain neuropsychological syndromes, such as age-associated memory impairment (Crook, Larrabee, & Youngjohn, 1990), mild traumatic brain injury (Paniak, MacDonald, Toller Lobe, Durand, & Nagy, 1998), and Alzheimer s disease (McKhann et al, 1984) in order to achieve homogeneity in group research One important difference between group and single-case approaches involves the use of replication as a tool for validating and strengthening scienti c conclusions In group.

The European E1 system, coding of segment 4 (positive).

1 Voldman S ESD: Physics and Devices Chichester: John Wiley & Sons, Ltd, 2004 2 Voldman S ESD: Circuits and Devices Chichester, England: John Wiley & Sons, Ltd, 2005 3 Voldman S, Gross V, Hargrove M, Never J, Slinkman J, O Boyle M, et al Shallow trench isolation (STI) double-diode electrostatic discharge (ESD) circuit and interaction with DRAM circuitry Proceedings of the Electrical Overstress/ Electrostatic Discharge (EOS/ESD) Symposium, 1992 p 277 288 4 Voldman S, Gross V, Hargrove M, Never J, Slinkman J, O Boyle M, et al Shallow trench isolation (STI) double-diode electrostatic discharge (ESD) circuit and interaction with DRAM circuitry Elsevier Journal of Electrostatics 1993;31(2 3):237 65 5 Voldman S, Gross V Scaling, optimization, and design considerations of electrostatic discharge protection circuits in CMOS technology Proceedings of the Electrical Overstress/ Electrostatic Discharge (EOS/ESD) Symposium, 1993 p 251 60 6 Voldman S, Gross V.